The effect of solvent choice on the gelation and final hydrogel properties of Fmoc-diphenylalanine
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Updated: Apr 19, 2026
Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
Published on: September 6, 2024
Jaclyn Raeburn1, Cristina Mendoza-Cuenca, Beatrice N Cattoz
1Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK. d.j.adams@liverpool.ac.uk.
Abstract:
Gels can be formed by dissolving Fmoc-diphenylalanine (Fmoc-PhePhe or FmocFF) in an organic solvent and adding water. We show here that the choice and amount of organic solvent allows the rheological properties of the gel to be tuned. The differences in properties arise from the microstructure of the fibre network formed. The organic solvent can then be removed post-gelation, without significant changes in the rheological properties. Gels formed using acetone are meta-stable and crystals of FmocFF suitable for X-ray diffraction can be collected from this gel.
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