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Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

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Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
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Biopesticides offer a sustainable alternative to chemical pesticides, utilizing microbial agents to control agricultural pests. Bacillus thuringiensis (Bt) is a widely employed bacterium known for its potent insecticidal activity. Bt biopesticides are favored for their specificity to insect pests, minimal environmental impact, and natural degradability.Mechanism of Bt Toxin Action Bt produces insecticidal crystal (Cry) proteins during its sporulation phase. These proteins form parasporal...
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Related Experiment Video

Updated: Apr 19, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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WIPO Re:Search: Accelerating anthelmintic development through cross-sector partnerships.

Roopa Ramamoorthi1, Katy M Graef1, Jennifer Dent1

  • 1BIO Ventures for Global Health, 401 Terry Avenue North, Seattle, WA 98109, United States.

International Journal for Parasitology. Drugs and Drug Resistance
|December 18, 2014
PubMed
Summary

The WIPO Re:Search consortium connects pharmaceutical resources with researchers to accelerate drug, vaccine, and diagnostic development for neglected tropical diseases, malaria, and tuberculosis.

Keywords:
AnthelminticCapacity-building experienceCross-sector collaborationWIPO Re:Search

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Area of Science:

  • Global Health
  • Drug Discovery
  • Intellectual Property

Background:

  • Neglected tropical diseases (NTDs), malaria, and tuberculosis affect 1.6 billion people globally.
  • Existing drug development pipelines for these diseases are insufficient.
  • Public-private partnerships are crucial for addressing these health challenges.

Purpose of the Study:

  • To describe the WIPO Re:Search consortium's model for accelerating product development for NTDs, malaria, and tuberculosis.
  • To highlight the role of BIO Ventures for Global Health (BVGH) as the Partnership Hub Administrator.
  • To report on the growth and impact of the WIPO Re:Search consortium.

Main Methods:

  • The WIPO Re:Search consortium connects pharmaceutical company assets (compound libraries, expertise) with academic/nonprofit researchers.
  • BVGH facilitates collaborations by matching researcher needs with member capabilities.
  • Membership growth and research agreement facilitation are tracked.

Main Results:

  • WIPO Re:Search has grown to over 90 member institutions globally since 2011.
  • Over 70 research agreements have been facilitated.
  • 11 collaborations specifically focus on anthelmintic drug discovery.

Conclusions:

  • The WIPO Re:Search model effectively fosters public-private partnerships for neglected disease research.
  • The consortium demonstrates a successful approach to connecting resources and expertise for global health product development.
  • Continued expansion and collaboration are key to addressing the burden of NTDs, malaria, and tuberculosis.