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Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
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Appendicitis01:19

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Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
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Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

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Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Inflammatory Bowel Disease IV: Clinical Manifestations01:20

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Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
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Inflammatory Bowel Disease I: Introduction01:26

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Appendiceal Crohn's disease clinically presenting as acute appendicitis.

Hulin Han1, Hyunsung Kim1, Abdul Rehman1

  • 1Hulin Han, Hyunsung Kim, Abdul Rehman, Se Min Jang, Seung Sam Paik, Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, South Korea.

World Journal of Clinical Cases
|December 18, 2014
PubMed
Summary

The incidence of appendiceal Crohn's disease (CD) was found to be 0.55% in this study. Characteristic histologic findings, including transmural inflammation and epithelioid granulomas, aid in diagnosing this condition.

Keywords:
Acute appendicitisAppendectomyAppendixCrohn’s diseasePrognosis

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Area of Science:

  • Gastroenterology
  • Pathology
  • Surgical Pathology

Background:

  • Crohn's disease (CD) is a chronic inflammatory bowel disease.
  • Appendiceal involvement in CD is infrequently recognized.

Purpose of the Study:

  • To determine the incidence of appendiceal Crohn's disease (CD).
  • To summarize the characteristic histologic features of appendiceal CD.

Main Methods:

  • Retrospective review of 2179 appendectomy specimens (January 2007 - May 2013).
  • Histologic evaluation for CD-specific features: transmural inflammation, granulomas, mucosal ulceration, crypt abscesses, fissures, and fistulas.

Main Results:

  • Appendiceal CD identified in 12 cases (0.55% incidence).
  • Common histologic findings included transmural inflammation (100%), epithelioid granulomas (100%), and appendiceal wall thickening (92%).
  • Symptoms varied, with right lower quadrant pain being frequent.

Conclusions:

  • Appendiceal CD presents with characteristic histologic features.
  • These features, along with clinical presentation, are crucial for diagnosis.