Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Cancer Therapies02:49

Cancer Therapies

9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
Analgesia and Pain Management01:25

Analgesia and Pain Management

1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
Cancer Vaccines01:30

Cancer Vaccines

946
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
946
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cauliflower-Like Liver Metastases from Colon Cancer.

Journal of Brown hospital medicine·2026
Same author

Against medical advice.

Journal of hospital medicine·2026
Same author

The Patient Who Stayed.

Australasian journal on ageing·2026
Same author

He was only thirty one.

Palliative & supportive care·2026
Same author

Unknown Chicago.

Journal of palliative medicine·2026
Same author

The Pain We Don't Trust.

Journal of palliative medicine·2026

Related Experiment Video

Updated: Jan 13, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

9.7K

Cancer Pain Is Not One-Size-Fits-All: Evolving from Tradition to Precision.

Nidha Shapoo1, Abdul Rehman1, Carlos Izaguirre-Rojas1

  • 1Department of Medicine, New York Medical College/Metropolitan Hospital, New York, NY 10029, USA.

Clinics and Practice
|October 28, 2025
PubMed
Summary

Cancer pain management is evolving from a one-size-fits-all approach to personalized strategies. A new five-domain framework helps tailor treatments for better patient outcomes in oncology.

Keywords:
WHO analgesic ladderbiomarkerscancer painchallengesemerging advancesevolutionpersonalized approachprecision medicine

More Related Videos

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.6K
Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.5K

Related Experiment Videos

Last Updated: Jan 13, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

9.7K
Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.6K
Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.5K

Area of Science:

  • Oncology
  • Pain Management
  • Precision Medicine

Background:

  • Cancer pain significantly impacts patient quality of life and prognosis.
  • Historical opioid-centric approaches often resulted in inadequate pain control.
  • Traditional algorithms struggle with the complex and heterogeneous nature of cancer pain.

Purpose of the Study:

  • To review the evolution of cancer pain management.
  • To highlight the potential of precision and personalized medicine.
  • To introduce a comprehensive five-domain framework for individualized cancer pain control.

Main Methods:

  • Literature review tracing historical and contemporary approaches.
  • Analysis of advances in pain assessment and multimodal analgesia.
  • Proposal of a five-domain framework (biological, pharmacologic, psychological, sociocultural, functional).

Main Results:

  • Contemporary management is shifting towards precision and personalized medicine.
  • A multidimensional framework enables tailored pain management strategies.
  • Integration of genetic, molecular, and biomarker data informs treatment decisions.

Conclusions:

  • A five-domain framework offers a comprehensive approach to individualized cancer pain management.
  • Precision oncology strategies promise improved pain control.
  • Addressing challenges like heterogeneity and data integration is crucial for equitable care.