Related Experiment Video
Updated: Apr 19, 2026

GC-based Detection of Aldononitrile Acetate Derivatized Glucosamine and Muramic Acid for Microbial Residue Determination in Soil
Published on: May 19, 2012
Efficient Approach To Discover Novel Agrochemical Candidates: Intermediate Derivatization Method
Changling Liu1, Aiying Guan1, Jindong Yang1
1State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Company Ltd. , Shenyang 110021, China.
The intermediate derivatization method (IDM) offers an efficient strategy for discovering novel agrochemicals. This approach accelerates the development of new biologically active molecules, addressing challenges in the agrochemical industry.
Area of Science:
- Agrochemical Science
- Medicinal Chemistry
- Organic Synthesis
Background:
- Traditional agrochemical discovery faces challenges including intellectual property competition, resistance development, and environmental regulations.
- Low success rates and long development times necessitate novel, efficient discovery approaches.
- The need for rapid innovation in agrochemicals to meet market demands is critical.
Purpose of the Study:
- To introduce and explain the intermediate derivatization method (IDM) as a novel strategy for agrochemical discovery.
- To highlight the advantages of IDM, including efficiency, reduced cost, and improved molecular structures.
- To demonstrate the application and success of IDM in accelerating the discovery of new biologically active agrochemical molecules.
Main Methods:
- Summarizing the principles and workflow of the intermediate derivatization method (IDM).
- Comparing IDM with conventional agrochemical discovery and novel pharmaceutical methods.
- Illustrating the practical application of IDM through case studies and research projects.
Main Results:
- IDM provides a relatively efficient discovery phase with reduced time and cost.
- The method facilitates the creation of innovative molecular structures with enhanced performance.
- Research programs utilizing IDM have shown an improved success rate in discovering new agrochemicals.
Conclusions:
- The intermediate derivatization method (IDM) is a promising strategy for accelerating the discovery of novel agrochemicals.
- IDM effectively addresses the limitations of traditional methods by offering efficiency and innovation.
- Successful implementation of IDM in research programs validates its utility in the agrochemical industry.
More Related Videos
Related Concept Videos
Preparation of 1° Amines: Gabriel Synthesis
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
Preparation of Alkynes: Dehydrohalogenation
Alkynes can be prepared by dehydrohalogenation of vicinal or geminal dihalides in the presence of a strong base like sodium amide in liquid ammonia. The reaction proceeds with the loss of two equivalents of hydrogen halide (HX) via two successive E2 elimination reactions.
Drug Discovery: Overview
Preparation of Alkynes: Alkylation Reaction
Alkylation of terminal alkynes with primary alkyl halides in the presence of a strong base like sodium amide is one of the common methods for the synthesis of longer carbon-chain alkynes. For example, treatment of 1-propyne with sodium amide followed by reaction with ethyl bromide yields 2-pentyne.
Preparation of 1° Amines: Azide Synthesis
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...

