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Updated: Apr 19, 2026

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
Published on: August 1, 2013
CD103+ dendritic cells producing interleukin-12 in anticancer immunosurveillance
Laurence Zitvogel1, Guido Kroemer2
1Gustave Roussy Cancer Campus, 94805 Villejuif, France; INSERM U1015, 94805 Villejuif, France; Université Paris Sud-XI, Faculté de Médecine, Le Kremlin Bicêtre, 91400 Orsay, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, 94805 Villejuif, France.
Abstract:
The mechanisms through which tumor antigen-specific T cells are elicited in natural or chemotherapy-induced immunosurveillance have been elusive. In this issue of Cancer Cell, two papers by Broz and colleagues and Ruffell and colleagues delineate an important role for a specific dendritic cell subset characterized by CD103 expression, dependence on transcription factors Batf3 and Irf8, and interleukin-12 production.
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