Related Experiment Video
Updated: Apr 19, 2026
05:18
Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
Published on: May 26, 2023
2.0K
[Short-term high-dose intravenous methylprednisolone therapy]
Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 19, 2014
Summary
Short-term, high-dose intravenous methylprednisolone therapy (IVMP) effectively treats multiple sclerosis (MS) and neuromyelitis optica (NMO) exacerbations by reducing inflammation. While generally safe, potential adverse events require monitoring.
Area of Science:
- Neuroimmunology
- Pharmacology
Context:
- Acute exacerbations of multiple sclerosis (MS) and neuromyelitis optica (NMO) require effective treatment.
- Intravenous methylprednisolone therapy (IVMP), or steroid pulse therapy, is a standard treatment for MS exacerbations.
Purpose:
- To summarize the efficacy and safety of IVMP in treating acute neurological conditions.
- To highlight alternative treatments for IVMP-refractory cases.
Summary:
- IVMP improves neurological symptoms in MS and benefits NMO patients.
- It functions by inhibiting inflammatory cascades, reducing cytokines, and suppressing T cell activation.
- Plasmapheresis may be considered for NMO patients unresponsive to IVMP.
Impact:
- IVMP is a well-tolerated and relatively safe therapeutic option.
- Monitoring for adverse events like psychosis, hyperglycemia, and osteonecrosis is crucial.
- This therapy offers significant benefits in managing acute inflammatory demyelinating diseases.
Related Concept Videos
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
689
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
689
01:14Myocarditis III: Medical Management
331
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
331
01:24Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
399
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
399
01:26COPD: Management Using Bronchodilators and Corticosteroids
1.2K
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
1.2K
01:17Pericarditis III: Medical Management
556
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
556