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Characterization of human papillomavirus subtype 72b
Hanna Johansson1, Evgenia Kravtchenko1, Ola Forslund2
1Department of Laboratory Medicine, Medical Microbiology, Lund University, Malmö, Sweden.
Genome Announcements
|December 20, 2014
Summary
We identified a new human papillomavirus (HPV) subtype, HPV72b, from an oral rinse sample. Its genetic similarity to HPV72 suggests it is a distinct type.
Area of Science:
- Virology
- Molecular Biology
- Public Health
Background:
- Human papillomavirus (HPV) infections are common globally.
- Certain HPV types are associated with various cancers.
- Oral HPV infections are increasingly recognized.
Purpose of the Study:
- To characterize a novel HPV subtype identified in an oral rinse sample.
- To determine the genetic relationship of the novel subtype to known HPV types.
Main Methods:
- Isolation and sequencing of the L1 open reading frame (ORF) of the novel HPV subtype.
- Bioinformatic analysis to compare the L1 ORF sequence with existing HPV types.
Main Results:
- Characterization of human papillomavirus (HPV) subtype 72b from an oral rinse sample.
- The HPV72b L1 ORF showed 90.2% identity to HPV72.
- This genetic similarity places HPV72b at the threshold for classification as a novel HPV type.
Conclusions:
- HPV subtype 72b represents a potentially new type within the Alphapapillomavirus genus.
- Further research is needed to understand the prevalence and clinical significance of HPV72b.
