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Type-2 innate lymphoid cells in asthma and allergy
1MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Annals of the American Thoracic Society
|December 20, 2014
Summary
Type-2 innate lymphoid cells (ILC2) are key immune cells involved in allergic diseases and metabolic homeostasis. Their role in chronic conditions and adaptive immunity highlights their potential as therapeutic targets.
Area of Science:
- Immunology
- Cell Biology
Background:
- Type-2 innate lymphoid cells (ILC2) are innate immune cells that produce type-2 cytokines like IL-5 and IL-13.
- ILC2 development is regulated by transcription factors RORα and GATA3 and originates from bone marrow progenitors.
Purpose of the Study:
- To summarize the multifaceted roles of ILC2 in immune responses, disease pathogenesis, and potential therapeutic applications.
Main Methods:
- Review of experimental models and patient data implicating ILC2 in various physiological and pathological conditions.
Main Results:
- ILC2 are involved in initiating type-2 immunity, contributing to allergic diseases (asthma, atopic dermatitis), and metabolic homeostasis.
- Emerging evidence suggests ILC2 also play roles in chronic pathologies like fibrosis and influence adaptive T-cell responses.
Conclusions:
- ILC2 are crucial players in both acute and chronic type-2 immune responses.
- The presence of ILC2 in allergic dermatitis and rhinitis patients suggests they are promising therapeutic targets for immune-mediated diseases.
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