Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

946
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
946
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K
Inflammatory Response01:28

Inflammatory Response

1.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.8K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

114
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
114
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

646
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
646
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

66.8K
Overview
66.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ILC2s regulate a fibroblast progenitor niche in the pancreas.

Science (New York, N.Y.)·2026
Same author

Bridging Rare to Common Diseases: Precision Medicine and the Transforming Landscape of Pediatric Allergy and Immunology.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Stable Dual-Functional Coating on Polyurethane Surface by Grafting Antibacterial-Zwitterionic Copolymer.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Structural Engineering of Biomass-Derived Hard Carbon With Architectured Closed Pores for Fast Sodium Storage.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Leveraging Artificial Intelligence in Allergy, Asthma, and Immunology With Environmental Exposures.

Allergy·2026
Same author

Choanal atresia repair in Europe and the world - a comprehensive investigation of the current state of care.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same journal

Dendritic Cell α-Ketoglutarate Regulates Tfh Polarization in Allergy.

Allergy·2026
Same journal

Decoding the "Metallic" Immune Imprint: Single-Cell Exposomics Reveals the Immune Imprint of Fire Smoke.

Allergy·2026
Same journal

Immunonutrition in Early Life: The Role of Complementary Feeding, Dietary Patterns, and Nutritional Exposures on the Health of Young Children-An EAACI Scoping Review.

Allergy·2026
Same journal

Detergent-Containing Toothpaste Decreases Esophageal Mucosal Impedance and Alters Salivary Properties in Humans.

Allergy·2026
Same journal

Global Variation in Timing of Allergenic Food Introduction for Food Allergy Prevention: An International Survey of Healthcare Professionals.

Allergy·2026
Same journal

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma.

Allergy·2026
See all related articles

Related Experiment Video

Updated: Jun 1, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

34.4K

IL-25 Enhances B Cell Responses in Type 2 Inflammation Through IL-17RB Receptor.

Semah Abdu1,2, Jiao Xia1,3, Huihui Yuan1,4

  • 1School of Immunology and Microbial Sciences, King's College London, London, UK.

Allergy
|January 20, 2025
PubMed
Summary
This summary is machine-generated.

Interleukin-25 (IL-25) receptor IL-17RB is expressed on B cells, which enhance antibody production when activated by IL-25. This IL-25/IL-17RB pathway is a potential therapeutic target for type 2 inflammatory diseases like CRSwNP.

Keywords:
B cellsIL‐17RBIL‐25IgEtype 2 inflammation

More Related Videos

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

2.5K
Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
07:46

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

2.8K

Related Experiment Videos

Last Updated: Jun 1, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

34.4K
Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

2.5K
Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
07:46

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

2.8K

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Alarmin cytokine IL-25 drives type 2 inflammation in asthma and CRSwNP.
  • IL-25 primarily targets ILC2 and Th2 cells, but other targets are unknown.

Purpose of the Study:

  • Investigate IL-25 receptor (IL-17RB) induction and expression on B cells.
  • Evaluate the in vitro responsiveness of IL-17RB-expressing B cells to IL-25.

Main Methods:

  • Flow cytometry and RT-PCR assessed IL-17RB expression on B cells.
  • Single-cell RNA sequencing compared IL-17RB+ and IL-17RB- B cells.
  • B cells from nasal polyps, control tissue, and peripheral blood were analyzed.

Main Results:

  • B cell activation increased IL-17RB expression, further upregulated by IL-25.
  • IL-17RB+ B cells responded to IL-25 with enhanced antibody production.
  • Nasal polyp B cells showed higher IL-17RB expression, correlating with CRSwNP severity.

Conclusions:

  • Activated B cells express IL-17RB, and its expression is increased in type 2 inflammation.
  • IL-17RB+ B cells have a unique profile and enhance antibody production upon IL-25 stimulation.
  • The IL-25/IL-17RB pathway presents a potential therapeutic target for type 2 inflammatory disorders.