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Updated: Apr 19, 2026
Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
Bladder cancer screening in aluminum smelter workers
Oyebode A Taiwo1, Martin D Slade, Linda F Cantley
1From the Yale Occupational and Environmental Medicine Program (Dr Taiwo, Ms Slade, Ms Cantley, Ms Tessier-Sherman, Mr Galusha, and Ms Kirsche), Yale University School of Medicine, New Haven, Conn; Alcoa, Inc (Dr Donoghue), Western Australia; and General Medical Disciplines (Dr Cullen), Stanford University School of Medicine, Calif.
Objective:
To present results of a bladder cancer screening program conducted in 18 aluminum smelters in the United States from January 2000 to December 2010.
Methods:
Data were collected on a cohort of workers with a history of working in coal tar pitch volatile exposed areas including urine analysis for conventional cytology and ImmunoCyt/uCyt+ assay.
Results:
ImmunoCyt/uCyt+ and cytology in combination showed a sensitivity of 62.30%, a specificity of 92.60%, a negative predictive value of 99.90%, and a positive predictive value of 2.96%. Fourteen cases of bladder cancer were detected, and the standardized incidence ratio of bladder cancer was 1.18 (95% confidence interval, 0.65 to 1.99). Individuals who tested positive on either test who were later determined to be cancer free had undergone expensive and invasive tests.
Conclusions:
Evidence to support continued surveillance of this cohort has not been demonstrated.
