Related Experiment Video
Updated: Apr 19, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
What can we expect from biomarkers for acute kidney injury?
John A Kellum1, Prasad Devarajan
1Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604, Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA.
Abstract:
Biomarkers for acute kidney injury have numerous potential roles to play both at the bedside and in the design and conduct of clinical trials. Given the heterogeneous nature of this disease and the difficulty, so far, in developing effective therapies, a strategy that deploys all of our available tools in the treatment and in study of treatments would seem prudent. In this review, we discuss how biomarkers will change the way we do we take care of patients with and do clinical trials in acute kidney injury and why, in fact, biomarkers are necessary.
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Acute Kidney Injury I: Introduction
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury II: Pathophysiology
Acute Kidney Injury III: Clinical Manifestations
Serum Studies: Renal Function Tests
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