Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

937
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
937
Bacterial Signaling01:30

Bacterial Signaling

43.7K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
43.7K
Global Regulatory Systems01:28

Global Regulatory Systems

940
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
940
Overview of Cell Signaling01:23

Overview of Cell Signaling

27.1K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
27.1K
Overview of Cell Signaling01:23

Overview of Cell Signaling

5.1K
5.1K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

8.0K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating theory and machine learning to reveal determinants of plasmid copy number.

Nature communications·2026
Same author

Mapping single-cell responses to population-level dynamics during antibiotic treatment.

Molecular systems biology·2026
Same author

A foundation model for microbial growth dynamics.

bioRxiv : the preprint server for biology·2026
Same author

Spatial proximity dictates bacterial competition and expansion in microbial communities.

Nature communications·2025
Same author

Dynamical memory underlies prolonged plasmid persistence after transient antibiotic treatment.

bioRxiv : the preprint server for biology·2025
Same author

Emergence of population-level feedback control by transposon-plasmid coevolution.

bioRxiv : the preprint server for biology·2025
Same journal

DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells.

Chemistry & biology·2015
Same journal

Differential Regulation of Specific Sphingolipids in Colon Cancer Cells during Staurosporine-Induced Apoptosis.

Chemistry & biology·2015
Same journal

Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase Iα.

Chemistry & biology·2015
Same journal

Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery.

Chemistry & biology·2015
Same journal

Vitamin C as Cancer Destroyer, Investigating Sulfhydration, and the Variability in CFTR Interactome.

Chemistry & biology·2015
Same journal

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

Chemistry & biology·2015
See all related articles

Related Experiment Video

Updated: Apr 19, 2026

Time-lapse Imaging of Bacterial Swarms and the Collective Stress Response
06:26

Time-lapse Imaging of Bacterial Swarms and the Collective Stress Response

Published on: May 23, 2020

9.0K

Emergent dynamics from quorum eavesdropping.

Jaydeep K Srimani1, Lingchong You1

  • 1Department of Biomedical Engineering, Center for Genomic and Computational Biology, Center for Systems Biology, Duke University, Durham, NC 27708, USA.

Chemistry & Biology
|December 20, 2014
PubMed
Summary
This summary is machine-generated.

Synthetic gene circuits untangle complex bacterial communication (quorum sensing) in mixed populations. This research clarifies quorum sensing crosstalk, aiding infectious disease and biosynthesis applications.

More Related Videos

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
07:47

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Published on: January 1, 2016

12.2K
Quantifying Bacterial Surface Swarming Motility on Inducer Gradient Plates
05:57

Quantifying Bacterial Surface Swarming Motility on Inducer Gradient Plates

Published on: January 5, 2022

4.5K

Related Experiment Videos

Last Updated: Apr 19, 2026

Time-lapse Imaging of Bacterial Swarms and the Collective Stress Response
06:26

Time-lapse Imaging of Bacterial Swarms and the Collective Stress Response

Published on: May 23, 2020

9.0K
Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
07:47

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Published on: January 1, 2016

12.2K
Quantifying Bacterial Surface Swarming Motility on Inducer Gradient Plates
05:57

Quantifying Bacterial Surface Swarming Motility on Inducer Gradient Plates

Published on: January 5, 2022

4.5K

Area of Science:

  • Microbiology
  • Synthetic Biology
  • Systems Biology

Background:

  • Bacterial populations use quorum sensing (QS) for communication.
  • Crosstalk between different QS systems complicates microbial community dynamics.
  • Understanding these interactions is crucial for controlling bacterial behavior.

Purpose of the Study:

  • To investigate the interactions between two distinct quorum sensing systems.
  • To utilize synthetic gene circuits as a tool to dissect QS crosstalk.
  • To explore potential applications in managing bacterial communities.

Main Methods:

  • Construction and implementation of synthetic gene circuits.
  • Engineering specific quorum sensing pathways.
  • Monitoring and analyzing communication dynamics in controlled environments.

Main Results:

  • Elucidation of specific crosstalk mechanisms between the studied QS systems.
  • Demonstration of synthetic circuits' efficacy in dissecting complex bacterial communication.
  • Identification of key regulatory points within the QS networks.

Conclusions:

  • Synthetic gene circuits provide a powerful platform for understanding bacterial QS.
  • Dissecting QS crosstalk is essential for predicting and controlling microbial population behavior.
  • This work has implications for fields including infectious disease management and metabolic engineering.