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The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Palmoplantar lichen planus.

Evan Rieder1, Christopher S Hale, Shane A Meehan

  • 1New York University School of Medicine.

Dermatology Online Journal
|December 20, 2014
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Summary
This summary is machine-generated.

Palmoplantar lichen planus (PPLP), a rare skin condition, showed improvement with methotrexate treatment. This occurred after acitretin therapy was unsuccessful for this patient.

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Palmoplantar lichen planus (PPLP) is an uncommon variant of lichen planus.
  • PPLP affects the palms and soles, presenting with varied clinical findings.

Observation:

  • Clinical presentations of PPLP can be categorized into erythematous scaly or hyperkeratotic patterns.
  • Histopathologic features align with classic lichen planus.

Findings:

  • A case of PPLP resistant to acitretin demonstrated significant improvement with methotrexate therapy.
  • Methotrexate offers a potential treatment option for refractory PPLP.

Implications:

  • This case highlights methotrexate as a viable therapeutic option for recalcitrant PPLP.
  • Further research into methotrexate's efficacy in PPLP is warranted.