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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
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Innate lymphoid cells in type 2 immune responses.
Ananda S Mirchandani1, Robert J Salmond
1Institute of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
Archivum Immunologiae Et Therapiae Experimentalis
|December 21, 2014
Summary
Group 2 innate lymphoid cells (ILC2) are key players in type 2 immunity. This review covers ILC2 development, function in infections and allergies, and interactions with T helper 2 cells.
Area of Science:
- Immunology
- Cell Biology
Background:
- Distinct innate lymphoid cell (ILC) populations, including Group 2 ILC (ILC2), have been identified in mammals.
- ILC2 are rapid responders in type 2 immune responses, crucial for parasitic infection immunity and inflammatory/allergic conditions.
Purpose of the Study:
- To review recent advancements in understanding ILC2 development and ontogeny.
- To explore the functional mechanisms of ILC2 in various infection and disease contexts.
- To highlight the interplay between ILC2 and adaptive CD4(+) T helper 2 (Th2) cells.
Main Methods:
- Literature review of recent research on ILC2.
- Analysis of studies on ILC2 development, function, and interactions.
Main Results:
- ILC2 play significant roles in immunity against parasitic infections.
- ILC2 are implicated in the pathology of inflammatory and allergic diseases.
- Emerging evidence shows functional interactions between ILC2 and CD4(+) Th2 cells.
Conclusions:
- ILC2 are critical innate immune cells with diverse roles in health and disease.
- Further research into ILC2 mechanisms and interactions can inform therapeutic strategies for immune-related disorders.
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