Related Experiment Video
Updated: Apr 19, 2026
09:47
Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
20.2K
Gingival wound healing: an essential response disturbed by aging?
P C Smith1, M Cáceres2, C Martínez3
1School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile psmithf@uc.cl.
Journal of Dental Research
|December 21, 2014
Summary
Aging significantly impairs gingival wound healing by affecting epithelial migration, tissue formation, and remodeling. Cellular and molecular defects contribute to these age-related healing deficiencies.
Area of Science:
- Oral biology
- Wound healing research
- Gerontology
Background:
- Gingival wound healing is crucial for preventing microbial invasion and managing tissue injury.
- Aging negatively impacts various stages of the wound-healing process.
- Defects in healing can influence inflammatory responses and cancer progression.
Purpose of the Study:
- To review the cellular and molecular mechanisms underlying age-related defects in gingival wound healing.
- To explore the clinical implications of impaired healing in aging individuals.
Main Methods:
- Review of recent experimental data on aging and gingival wound healing.
- Analysis of cellular and molecular alterations in healing phases.
Main Results:
- Aging affects epithelial migration, granulation tissue formation, and remodeling.
- Key defects include increased inflammation, altered integrin signaling, reduced growth factors, and impaired stem cell function.
- Diminished angiogenesis and altered collagen synthesis/remodeling are also observed.
Conclusions:
- Aging introduces significant cellular and molecular deficits that compromise gingival wound healing.
- Understanding these defects is vital for addressing clinical implications in the aging population.
Related Concept Videos
01:19The Effect of Aging on Tissues
4.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.2K
01:29Bone Disorders
8.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.8K
01:28Phases of Wound Repair
10.0K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
10.0K
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
346
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
346
01:24Inflammatory Response II: Inflammatory Exudate and Tissue Repair
9.7K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
9.7K
01:27The Oral Microbiota
61
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
61