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Current and emerging options for taxol production.

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Paclitaxel (Taxol) is a potent anticancer compound derived from the Pacific yew tree. This chapter explores biosynthetic strategies for its reliable production using various plant and microbial hosts.

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Area of Science:

  • Natural Product Chemistry
  • Biotechnology
  • Pharmacology

Background:

  • Paclitaxel (Taxol) is a plant-derived isoprenoid with significant anticancer properties.
  • Its isolation from the Pacific yew tree initiated efforts for reliable patient supply.
  • Production challenges necessitate exploring synthetic and biosynthetic routes.

Purpose of the Study:

  • To review current and emerging biosynthetic production strategies for Paclitaxel (Taxol).
  • To highlight the use of various plant species and microbial hosts for Taxol biosynthesis.
  • To discuss the elucidation, transfer, and reconstitution of the Taxol pathway in advanced microbial systems.

Main Methods:

  • Focus on biosynthetic pathways and production hosts for Paclitaxel.
  • Examination of macroscopic and unicellular plant species for Taxol production.
  • Analysis of microbial hosts engineered for Taxol pathway reconstitution.

Main Results:

  • Biosynthetic strategies offer viable alternatives for Taxol production.
  • Plant-derived and microbial systems are being optimized for yield and efficiency.
  • Elucidation of the Taxol pathway enables its transfer to microbial hosts.

Conclusions:

  • Biosynthesis presents a promising avenue for sustainable and scalable Paclitaxel (Taxol) production.
  • Advancements in metabolic engineering are crucial for efficient microbial production.
  • This review provides insights into producing complex natural products via biosynthesis.