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Reviving the protein quality control system: therapeutic target for cardiac disease in the elderly

Roelien A M Meijering1, Robert H Henning1, Bianca J J M Brundel1

  • 1Department of Clinical Pharmacy and Pharmacology, EB71, University Institute for Drug Exploration (GUIDE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Trends in Cardiovascular Medicine
|December 23, 2014
PubMed

Insights

Ageing impairs cellular protein homeostasis, leading to misfolded proteins that cause cardiac disease. Boosting the protein quality control (PQC) system may offer new therapies for heart conditions in older adults.

Area of Science:

  • Cardiovascular Science
  • Aging Research
  • Molecular Biology

Background:

  • Aging is a primary risk factor for cardiac disease, but underlying mechanisms remain unclear.
  • Cellular protein homeostasis loss, leading to misfolded proteins, is a key aging theory.
  • Impaired protein quality control (PQC) is linked to neurodegenerative diseases and increasingly to cardiac conditions.

Purpose of the Study:

  • To review the protein quality control (PQC) system in the context of aging.
  • To discuss the emerging role of PQC loss in cardiomyocytes as a trigger for cardiac disease.
  • To explore therapeutic strategies targeting PQC enhancement for age-related heart disease.

Main Methods:

  • Literature review of aging and protein quality control mechanisms.
  • Analysis of the role of proteotoxicity in cellular integrity.
  • Discussion of PQC system's relevance to cardiac pathophysiology.

Main Results:

  • Aging compromises cellular protein homeostasis, resulting in proteotoxic misfolded proteins.
  • Impaired PQC contributes to the pathophysiology of age-related cardiac diseases like atrial fibrillation, hypertrophy, and cardiomyopathy.
  • Loss of PQC in cardiomyocytes is a potential trigger for cardiac dysfunction.

Conclusions:

  • The decline in protein quality control (PQC) during aging is implicated in cardiac disease development.
  • Enhancing the PQC system presents a promising therapeutic avenue for treating elderly patients with heart conditions.
  • Targeting PQC offers innovative treatment strategies for age-related cardiac ailments.

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