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Detection of herpes simplex virus DNA in a cutaneous squamous cell carcinoma by in situ hybridization
A L Claudy1, M C Chignol, Y Chardonnet
1Service de Dermatologie, University Hospital, CHRU, St Etienne, France.
Archives of Dermatological Research
|January 1, 1989
Abstract:
A case of a cutaneous squamous cell carcinoma (SCC) occurring at the site of a long-standing recurrent HSV infection is described. No deficit of the cell-mediated immunity was recorded. HSV2 was isolated in several viral cultures. HSV DNA was visualized in the SCC by in situ hybridization with biotinylated probes in paraffin-embedded tissue. The samples were negative for HPV2, 5, 16, and 18 probes. A causal relationship between HSV infection and cutaneous SCC is hypothesized.