International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Progress to Date and Future Plans

Area of Science:

• Veterinary Pathology
• Toxicology
• Comparative Pathology

Background:

• The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice (INHAND) initiative began in 2005.
• Global collaboration involving experts from North America, Europe, and Japan manages INHAND objectives and terminology development.
• Organ Working Groups are responsible for harmonizing nomenclature across different organ systems.

Purpose of the Study:

• To provide an update on the progress of the INHAND project.
• To highlight the development and publication of harmonized nomenclature for rodent lesions.
• To emphasize the utility of INHAND guides in toxicologic and carcinogenicity studies.

Main Methods:

• Management of INHAND by a Global Editorial Steering Committee.
• Development of harmonized terminology by Organ Working Groups.
• Publication of nomenclature guides in scientific journals and online.

Main Results:

• Nine organ systems have had harmonized nomenclature published to date.
• Published systems include respiratory, hepatobiliary, urinary, nervous, reproductive, mammary, zymbal, clitoral, preputial, integument, and soft tissue.
• INHAND nomenclature guides include diagnostic criteria, lesion guidelines, photomicrographs, pathogenesis information, and references.

Conclusions:

• Significant progress has been made in standardizing lesion terminology in rats and mice.
• INHAND guides are valuable resources for consistent recording and interpretation of rodent study findings.
• Continued development and dissemination of INHAND resources are crucial for toxicologic pathology.