Related Experiment Video
Updated: Apr 19, 2026

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
Published on: March 1, 2022
[Bone and Calcium Research Update 2015. Metabolic crosstalk bone and other organs]
1Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Japan.
Abstract:
Bone homeostasis is maintained by bone formation and bone resorption. The identification that nervous system controls bone metabolism through leptin deficient mice studies opened a new field in bone biology. Notably, sympathetic and parasympathetic nerve system regulate bone metabolism. In addition, sensory nerve system also has been shown to be involved in the regulation of bone homeostasis. On the other hand, recent studies reported that bone derived hormones, such as osteocalcin or fibroblast growth factor 23, regulate systemic metabolism. Based on these findings, currently the bone-organ crosstalk has been noted.
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