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[Bone and Calcium Research Update 2015. Regulation of calcium in CKD]

Yoshitaka Isaka1, Hiromi Rakugi

  • 1Division of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Japan.

Clinical Calcium
|December 23, 2014
PubMed

Insights

Chronic kidney disease (CKD) patients face high cardiovascular risks and mineral bone disorder. This disorder involves abnormal calcium regulation by organs like the kidney and parathyroid, influenced by hormones and uremia.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Medicine

Context:

  • Patients with chronic kidney disease (CKD) exhibit a high predisposition to cardiovascular diseases.
  • CKD is associated with mineral and bone abnormalities, including bone disease and vascular calcification.
  • These complications are recognized as components of the novel concept 'chronic kidney disease-mineral bone disorder' (CKD-MBD).

Purpose:

  • To elucidate the complex interplay of organs and factors regulating calcium homeostasis in CKD.
  • To understand the pathophysiology of mineral and bone disorders in CKD patients.
  • To highlight the impact of CKD-MBD on patient outcomes.

Summary:

  • The regulation of serum calcium concentration is a coordinated process involving multiple organs: kidney, parathyroid, bone, and intestine.
  • Key factors influencing calcium regulation in CKD include parathyroid hormone, phosphate, vitamin D, and uremia.
  • These factors collectively contribute to the development of CKD-MBD and its associated complications.

Impact:

  • Improved understanding of CKD-MBD pathophysiology.
  • Potential for targeted therapeutic strategies to manage mineral and bone abnormalities in CKD.
  • Reduced cardiovascular risk and improved bone health in CKD patients.

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