Related Experiment Video

Updated: Apr 19, 2026

Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans
07:35

Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans

Published on: February 4, 2014

12.0K

Treating methamphetamine-induced resistant psychosis with clozapine

Ruohollah Seddigh1, Amir-Abbas Keshavarz-Akhlaghi1, Behnam Shariati1

  • 1Mental Health Research Center, Faculty of Behavioral Sciences and Mental Health, Tehran Institute of Psychiatry, Iran University of Medical Sciences, Tehran, Iran.

Case Reports in Psychiatry
|December 23, 2014
PubMed

Insights

Clozapine effectively treated two cases of methamphetamine-induced psychosis (MIP) resistant to other antipsychotics. Both patients showed complete recovery within two weeks and maintained remission during follow-up, suggesting clozapine

Area of Science:

  • Psychiatry
  • Pharmacology
  • Toxicology

Background:

  • Methamphetamine-induced psychosis (MIP) presents a significant public health challenge in Iran.
  • Resistant cases of MIP lack established effective treatment options.
  • Current antipsychotic treatments have shown limited efficacy in managing severe MIP.

Purpose of the Study:

  • To report on the successful treatment of two clozapine-resistant methamphetamine-induced psychosis (MIP) cases.
  • To evaluate the efficacy and safety of clozapine in treating refractory MIP.

Main Methods:

  • Two patients diagnosed with treatment-resistant methamphetamine-induced psychosis (MIP) were treated with clozapine.
  • Treatment response was monitored over an 8-9 week follow-up period.
  • Clinical outcomes, including psychotic symptom resolution and relapse, were assessed.

Main Results:

  • Both patients achieved complete remission of psychotic symptoms within two weeks of initiating clozapine treatment.
  • No signs of psychosis relapse were observed during the 8-9 week follow-up period.
  • Clozapine was well-tolerated in both cases.

Conclusions:

  • Clozapine demonstrates significant potential as an effective treatment for methamphetamine-induced psychosis (MIP), particularly in treatment-resistant cases.
  • The unique pharmacological profile of clozapine may contribute to its efficacy in managing complex psychosis.
  • Further research is warranted to confirm these findings in larger patient cohorts.

More Related Videos

Development of a Virtual Reality Assessment of Everyday Living Skills10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

19.5K
Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder11:17

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Published on: November 25, 2025

966

Related Concept Videos

Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
693
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.2K
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
424
Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
1.3K
Antipsychotic Drugs: Therapeutic Uses and Side Effects01:21

Antipsychotic Drugs: Therapeutic Uses and Side Effects

Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
1.2K
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
808