Related Experiment Video

Updated: Apr 19, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.7K

Individualization of dialysate calcium concentration according to baseline pre-dialysis serum calcium

Emilio Gonzalez-Parra1, Maria Luisa Gonzalez-Casaus, Maria Dolores Arenas

  • 1Division of Nephrology and Hypertension, IIS-Fundación Jiménez Díaz, Madrid, Spain.

Blood Purification
|December 23, 2014
PubMed

Insights

Individualizing dialysate calcium concentration for hemodialysis patients based on pre-dialysis serum calcium levels can prevent significant fluctuations in post-dialysis calcium and parathyroid hormone (PTH). This approach optimizes bone and mineral metabolism during dialysis.

Area of Science:

  • Nephrology
  • Bone and Mineral Metabolism
  • Cardiovascular Health

Background:

  • Positive calcium balance is linked to vascular calcification.
  • Negative calcium balance is associated with increased parathyroid hormone (PTH).
  • Dialysate calcium concentration impacts bone and mineral metabolism in hemodialysis patients.

Purpose of the Study:

  • To investigate the effects of varying dialysate calcium concentrations on bone and mineral metabolism.
  • To determine optimal dialysate calcium levels based on pre-dialysis serum calcium.

Main Methods:

  • A crossover study involving 56 hemodialysis patients.
  • Patients were dialyzed with either 3.0 mEq/l or 2.5 mEq/l dialysate calcium for two weeks.
  • Measurements of bone mineral metabolites were taken before and after dialysis sessions.

Main Results:

  • Higher dialysate calcium (3.0 mEq/l) resulted in greater increases in post-dialysis total and ionized calcium compared to 2.5 mEq/l.
  • Minimal changes in calcium and PTH were observed in patients with pre-dialysis serum calcium <8.75 mg/dl using 2.5 mEq/l dialysate.
  • Patients with pre-dialysis serum calcium >9.15 mg/dl showed the mildest changes when dialyzed with 3.0 mEq/l calcium.

Conclusions:

  • Individualizing dialysate calcium concentration is crucial.
  • Tailoring dialysate calcium to pre-dialysis serum calcium levels can prevent significant post-dialysis serum calcium and PTH level changes.
  • This personalized approach may improve bone and mineral metabolism management in hemodialysis.
Abstract

More Related Videos

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli12:19

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

11.7K
Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry10:24

Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry

Published on: October 28, 2014

15.9K

Related Concept Videos

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
339
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
367
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
2.3K
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
2.1K
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
1.7K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
9.6K