Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

718
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
718
Bone Disorders01:29

Bone Disorders

8.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.8K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

650
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
650
Diabetic Retinopathy01:27

Diabetic Retinopathy

11
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
11
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

7
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor,...
7
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

1.0K
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Fibrous dysplasia].

Orthopadie (Heidelberg, Germany)·2024
Same author

Uncertainty about others' trustworthiness increases during adolescence and guides social information sampling.

Scientific reports·2022
Same author

The SOFIA pilot trial: a cluster-randomized trial of coordinated, co-produced care to reduce mortality and improve quality of life in people with severe mental illness in the general practice setting.

Pilot and feasibility studies·2021
Same author

The learning curve of patient-specific unikondylar arthroplasty may be advantageous to off-the-shelf implants: A preliminary study.

Journal of orthopaedics·2020
Same author

Radiological outcome after treatment of juvenile flatfeet with subtalar arthroereisis: a matched pair analysis of 38 cases comparing neurogenic and non-neurogenic patients.

Journal of children's orthopaedics·2019
Same author

[Epiphyseolysis capitis femoris].

Der Orthopade·2019
Same journal

Chronic Osteomyelitis - Pathophysiology and Treatment.

Zeitschrift fur Orthopadie und Unfallchirurgie·2026
Same journal

Posterior Malleolus Fractures of the Tibia: Open Reduction and Buttress Plating versus Percutaneous Fixation with an Anteroposterior Screw.

Zeitschrift fur Orthopadie und Unfallchirurgie·2026
Same journal

Ultrasound Assessment of Talar, Femoral and Metacarpal Cartilage Thicknesses in Hemiplegic Patients and their Relationship with Functional Parameters.

Zeitschrift fur Orthopadie und Unfallchirurgie·2026
Same journal

Current Concepts in Acute and Chronic Lateral Ankle Instability.

Zeitschrift fur Orthopadie und Unfallchirurgie·2026
Same journal

Zeitschrift fur Orthopadie und Unfallchirurgie·2026
Same journal

Zeitschrift fur Orthopadie und Unfallchirurgie·2026
See all related articles

Related Experiment Video

Updated: Apr 19, 2026

Harvesting of Peroneus Longus Tendon Autograft
04:03

Harvesting of Peroneus Longus Tendon Autograft

Published on: September 2, 2025

2.2K

[Perthes disease].

B Westhoff1, F Martiny1, R Krauspe1

  • 1Orthopädische Klinik, Universitätsklinikum Düsseldorf.

Zeitschrift Fur Orthopadie Und Unfallchirurgie
|December 23, 2014
PubMed
Summary
This summary is machine-generated.

Perthes disease remains a challenge due to its unclear cause and debated treatments. Prognosis hinges on clinical and radiological factors, with range of motion and containment being key therapeutic targets.

More Related Videos

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.4K
Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research
04:37

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

Published on: March 1, 2024

1.5K

Related Experiment Videos

Last Updated: Apr 19, 2026

Harvesting of Peroneus Longus Tendon Autograft
04:03

Harvesting of Peroneus Longus Tendon Autograft

Published on: September 2, 2025

2.2K
Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.4K
Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research
04:37

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

Published on: March 1, 2024

1.5K

Area of Science:

  • Orthopaedic surgery
  • Paediatric orthopaedics
  • Hip joint biomechanics

Context:

  • Perthes disease presents ongoing challenges in aetiology and treatment.
  • Prognosis is influenced by clinical factors like age and reduced range of motion, and radiological factors such as necrosis extent and containment.
  • Therapeutic interventions focus on addressing reduced range of motion and loss of containment.

Purpose:

  • To review the current understanding and management of Perthes disease.
  • To highlight the importance of clinical and radiological parameters in predicting prognosis.
  • To discuss the role of surgical interventions like pelvic osteotomies.

Summary:

  • Pelvic osteotomies offer significant corrective potential without the biomechanical drawbacks of other procedures.
  • Current treatment paradigms consider orthoses obsolete.
  • Management of non-containment focuses on symptomatic relief and correcting residual deformities.

Impact:

  • Effective management of Perthes disease can mitigate the risk of premature osteoarthritis and the need for early total hip replacement.
  • Understanding prognostic factors aids in tailoring treatment strategies.
  • Advancements in surgical techniques like pelvic osteotomies improve outcomes for patients with Perthes disease.