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Updated: Apr 19, 2026

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
Published on: April 5, 2016
Fear generalization in the primate amygdala
1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Abstract:
Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.
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