Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Oppositely Charged Single Enzyme Nanogels Form Versatile Coacervates for Efficient Enzyme Cascade Catalysis.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Engineering a Transmembrane Receptor for Coacervate-Based Artificial Cells.

Journal of the American Chemical Society·2026

Same author

Probing Li-ion conduction in glassy Li<sub>2</sub>S-P<sub>2</sub>S<sub>5</sub> electrolytes using NMR.

Solid state nuclear magnetic resonance·2026

Same author

Converging frontiers in biomolecular condensate and synthetic cell research.

npj biomedical innovations·2026

Same author

Bio-Propelled Stomatocyte Nanomotors with Glutathione-Responsiveness for Osteoarthritis Treatment.

Angewandte Chemie (International ed. in English)·2026

Same author

Reconfiguration of Multiphase Coacervate Droplets Into Self-Regulated Nested Artificial Cells.

Angewandte Chemie (International ed. in English)·2026

Search research articles

Related Experiment Video

Updated: Apr 19, 2026

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

A fast and activatable cross-linking strategy for hydrogel formation.

Anika M Jonker¹, Annika Borrmann, Ernst R H van Eck

¹Heyendaalseweg 135, 6525, AJ, Nijmegen, The Netherlands.

Advanced Materials (Deerfield Beach, Fla.)

|December 24, 2014

Summary

Strain-promoted oxidation-controlled cyclo-octyne-1,2-quinone cycloaddition (SPOCQ) offers rapid hydrogel formation via oxidation. This versatile method allows for one-pot functionalization using click chemistry, enhancing hydrogel applications.

Keywords:

activatable cross-linking hydrogel oxidation

More Related Videos

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering

Published on: October 26, 2009

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

Related Experiment Videos

Last Updated: Apr 19, 2026

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering

Published on: October 26, 2009

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

Area of Science:

Polymer Chemistry
Biomaterials Science
Organic Synthesis

Background:

Hydrogel formation is crucial for various applications, requiring efficient and controllable cross-linking strategies.
Existing methods may lack speed, require harsh conditions, or limit post-formation functionalization.

Purpose of the Study:

To introduce and characterize a novel, fast, and activatable hydrogel formation strategy.
To demonstrate the utility of strain-promoted oxidation-controlled cyclo-octyne-1,2-quinone cycloaddition (SPOCQ) for hydrogel synthesis.
To showcase the potential for one-pot functionalization of SPOCQ-formed hydrogels.

Main Methods:

Utilized strain-promoted oxidation-controlled cyclo-octyne-1,2-quinone cycloaddition (SPOCQ) for hydrogel cross-linking.
Induced gelation via chemical oxidation (sodium periodate) and enzymatic oxidation (mushroom tyrosinase).
Employed strain-promoted azide-alkyne cycloaddition (SPAAC) for one-pot functionalization of the resulting hydrogels.

Main Results:

SPOCQ enables rapid hydrogel formation through oxidation-induced cross-linking.
Gelation can be controlled using both chemical and enzymatic oxidation methods.
The fast kinetics of SPOCQ allow for efficient in-situ functionalization via SPAAC.

Conclusions:

SPOCQ is a highly effective and rapid method for synthesizing functional hydrogels.
The dual chemical and enzymatic oxidation options provide flexibility in hydrogel preparation.
The ability for one-pot functionalization significantly expands the utility of SPOCQ-based hydrogels in advanced applications.