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Updated: Apr 19, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
[Histaminergic angioedema and chronic urticaria]
Florence Hacard1, Audrey Nosbaum1, Benoit Bensaid2
1Hospices civils de Lyon, centre hospitalier Lyon-Sud, service d'allergologie et d'immunologie clinique, 69495 Pierre-Bénite, France; Inserm U1111-CIRI/UMS3444/US8, 21, avenue Tony-Garnier, 69007 Lyon, France; Université Claude-Bernard Lyon I, UFR médecine Lyon-Sud Charles-Mérieux, 69921 Oullins cedex, France.
Abstract:
Most angioedemas are histaminergic and correspond to deep urticarial swelling. Recurrent histaminergic angioedema led to the diagnosis of chronic urticaria, even when there are no superficial associated hives. Chronic urticaria is a benign disease, and autoimmune in 40 % of cases. The occurrence of angioedema in chronic urticaria is not a sign of severity. The occurrence of angioedema in chronic urticaria is associated with a longer duration of urticarial disease. NSAIDs and/or systemic corticotherapy are classic triggers of angioedema in chronic urticaria. In the absence of clinical endpoints, there is no need to make further assessment in chronic urticaria good responders to antihistamines.
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