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Updated: Apr 19, 2026
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Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
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[Histaminergic angioedema and chronic urticaria]
Florence Hacard1, Audrey Nosbaum1, Benoit Bensaid2
1Hospices civils de Lyon, centre hospitalier Lyon-Sud, service d'allergologie et d'immunologie clinique, 69495 Pierre-Bénite, France; Inserm U1111-CIRI/UMS3444/US8, 21, avenue Tony-Garnier, 69007 Lyon, France; Université Claude-Bernard Lyon I, UFR médecine Lyon-Sud Charles-Mérieux, 69921 Oullins cedex, France.
Presse Medicale (Paris, France : 1983)
|December 24, 2014
Summary
Most cases of angioedema are histaminergic, often linked to chronic urticaria. Angioedema occurrence in chronic urticaria isn't a severity indicator but suggests a longer disease duration.
Area of Science:
- Immunology
- Dermatology
- Allergy
Context:
- Angioedema is frequently histaminergic, presenting as deep swelling, and recurrent episodes can lead to a chronic urticaria diagnosis.
- Chronic urticaria, while benign, is autoimmune in 40% of cases and can manifest with angioedema.
- Angioedema in chronic urticaria is not indicative of disease severity but is associated with a prolonged disease course.
Purpose:
- To clarify the relationship between angioedema and chronic urticaria.
- To inform clinical assessment and management strategies for patients with chronic urticaria and angioedema.
Summary:
- Histaminergic angioedema is common and can be the sole manifestation leading to a chronic urticaria diagnosis.
- The presence of angioedema in chronic urticaria correlates with longer disease duration, not severity.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) and systemic corticosteroids are identified triggers for angioedema in this context.
Impact:
- Highlights that angioedema in chronic urticaria does not necessitate further investigation if the patient responds well to antihistamines.
- Emphasizes the benign nature of chronic urticaria, even when angioedema is present.
- Provides clarity on the prognostic implications of angioedema in chronic urticaria.
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