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Updated: Apr 19, 2026
09:29
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
12.1K
[Evolution of Devic's neuromyelitis optica spectrum disorders].
Raphaël Bernard-Valnet1, Romain Marignier2
1Centre de physiopathologie de Toulouse Purpan, Inserm U1043, CNRS, UMR 5282, 31024 Toulouse cedex 03, France.
Presse Medicale (Paris, France : 1983)
|December 24, 2014
Summary
Neuromyelitis optica (NMO) is an autoimmune disease targeting the optic nerve and spinal cord, often marked by aquaporin-4 autoantibodies (AQP4-Ab). Understanding AQP4-Ab is key to diagnosing and treating this condition.
Area of Science:
- Neuroimmunology
- Autoimmune disorders
- Central nervous system inflammation
Context:
- Neuromyelitis optica (NMO) is a rare inflammatory CNS disorder.
- Recent advances have significantly improved NMO understanding and care.
- Aquaporin-4 autoantibodies (AQP4-Ab) are a hallmark of NMO.
Purpose:
- To review the evolving understanding of NMO.
- To discuss the role of AQP4-Ab in NMO pathophysiology.
- To explore current and emerging therapeutic strategies for NMO.
Summary:
- NMO definition is shifting towards a biological basis (aquaporinopathy) due to AQP4-Ab.
- AQP4-Ab contributes to NMO via neuroinflammation and neuromodulation.
- Effective NMO relapse prevention involves immunosuppression targeting B-cells, distinct from MS therapies.
- Seronegative NMO patients present unique features, necessitating further research.
Impact:
- Advances in NMO diagnostics and treatment.
- Improved patient outcomes through targeted therapies.
- Highlights the need for research into seronegative NMO cases.
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