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Serum calprotectin: review of its usefulness and validity in paediatric rheumatic diseases

Anthea Mariani1, Manuela Marsili1, Manuela Nozzi1

  • 1Department of Paediatrics, University of Chieti, Chieti, Italy.

Clinical and Experimental Rheumatology
|December 24, 2014
PubMed

Insights

Calprotectin, an inflammation molecule, shows promise as a diagnostic marker for childhood rheumatic diseases. Elevated levels correlate with disease activity, aiding in diagnosis where specific markers are lacking.

Area of Science:

  • Biochemistry
  • Immunology
  • Pediatrics

Background:

  • Specific diagnostic markers are often unavailable for childhood rheumatic diseases.
  • Calprotectin (MRP8/MRP14) is an inflammation molecule released by leukocytes.
  • Elevated calprotectin is observed in various chronic inflammatory conditions.

Purpose of the Study:

  • To review the validity and applications of calprotectin as an inflammation marker.
  • To explore calprotectin's potential in diagnosing pediatric rheumatic diseases.

Main Methods:

  • Literature review of studies on calprotectin in inflammatory diseases.
  • Analysis of calprotectin's correlation with disease activity and inflammatory markers (CRP, ESR).

Main Results:

  • Increased plasma calprotectin levels are found in chronic inflammatory diseases.
  • Serum calprotectin correlates with disease activity and inflammation markers like CRP and ESR.
  • Calprotectin shows potential as a novel inflammation marker in pediatric rheumatic diseases.

Conclusions:

  • Calprotectin is a promising inflammation marker for childhood rheumatic diseases.
  • Its levels correlate with disease severity, offering diagnostic utility.
  • Further research can validate its application in pediatric rheumatology.

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