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Updated: Apr 19, 2026

Pull-down of Calmodulin-binding Proteins
Published on: January 23, 2012
Calmodulin inhibitors from natural sources: an update
Rachel Mata1, Mario Figueroa1, Martín González-Andrade1
1†Facultad de Química and ‡Facultad de Medicina, Universidad Nacional Autónoma de México, México DF 04510, Mexico.
Abstract:
Calmodulin (CaM) plays a central role in regulating a myriad of cellular functions in physiological and pathophysiological processes, thus representing an important drug target. In previous reviews, our group has reported relevant information regarding natural anti-CaM compounds up to 2009. Natural sources continue to provide a diverse and unique reservoir of CaM inhibitors for drug and research tool discovery. This review provides an update of natural products with reported CaM inhibitory properties, which includes around 70 natural products and some synthetic analogues, belonging to different structural classes. Most of these natural inhibitors were isolated from fungi and plants and belong to the stilbenoid, polyketide, alkaloid, and peptide structural classes. These products were discovered mainly using a fluorescence-based method on rationally designed biosensors, which are highly specific, low-cost, and selective and have short reaction times. The effect of several antimitotic drugs on Ca(2+)-hCaM is also described.
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