Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

7.2K
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
7.2K
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship01:22

Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

2.6K
Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
The direct-acting...
2.6K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.9K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.9K
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship01:29

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

3.1K
Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...
3.1K
Positive Regulator Molecules01:45

Positive Regulator Molecules

137.4K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
137.4K
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers01:20

Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers

2.8K
Class IV antiarrhythmic drugs, such as verapamil and diltiazem, block calcium channels. They primarily affect the heart, slowing the conduction in calcium-dependent tissues like the SA and AV nodes. These drugs manage reentrant supraventricular tachycardia (SVT) and reduce ventricular rate in atrial flutter/fibrillation.
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uncompetitive Allosteric Inhibition of PTP1B by BP-1-102 Reveals a Potential Dual-Target Strategy toward the PTP1B-STAT3 Oncogenic Axis: Biochemical and Computational Evidence.

ACS medicinal chemistry letters·2026
Same author

Cementum Attachment Protein-Derived Peptides Modulate Brushite and Calcium Oxalate Crystallization In Vitro.

Journal of peptide science : an official publication of the European Peptide Society·2026
Same author

Assessment of the metabolic potential and transformation of aliphatic and polycyclic aromatic hydrocarbons by marine fungi from Mexican coastal and deep-sea environments.

Marine environmental research·2026
Same author

Sustainable Biocontrol of Agave Vascular Wilt Using an Inactivated Mycelial Formulation from the Mangrove Endophyte <i>Talaromyces islandicus</i> M31.

ACS omega·2026
Same author

Phytochemical and Nutritional Characterization of Porophyllum linaria: Novel Cyclopropane-Containing Waxes and Comparative Analysis With P. macrocephalum.

Chemistry & biodiversity·2026
Same author

Comparative Antinociceptive Evaluation of Hofmeisterin I and Analogues from <i>Hofmeisteria schaffneri</i> in Zebrafish and Mice.

ACS omega·2026

Related Experiment Video

Updated: Apr 19, 2026

Pull-down of Calmodulin-binding Proteins
07:51

Pull-down of Calmodulin-binding Proteins

Published on: January 23, 2012

26.1K

Calmodulin inhibitors from natural sources: an update.

Rachel Mata1, Mario Figueroa1, Martín González-Andrade1

  • 1†Facultad de Química and ‡Facultad de Medicina, Universidad Nacional Autónoma de México, México DF 04510, Mexico.

Journal of Natural Products
|December 24, 2014
PubMed
Summary

Natural products from fungi and plants are a rich source of calmodulin (CaM) inhibitors. This review updates the discovery of around 70 natural compounds and synthetic analogues with CaM inhibitory properties.

More Related Videos

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

3.1K
Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control
07:13

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control

Published on: May 24, 2024

1.1K

Related Experiment Videos

Last Updated: Apr 19, 2026

Pull-down of Calmodulin-binding Proteins
07:51

Pull-down of Calmodulin-binding Proteins

Published on: January 23, 2012

26.1K
Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

3.1K
Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control
07:13

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control

Published on: May 24, 2024

1.1K

Area of Science:

  • Biochemistry
  • Pharmacology
  • Natural Product Chemistry

Background:

  • Calmodulin (CaM) is a crucial protein regulating numerous cellular functions.
  • CaM is an important drug target for various physiological and pathophysiological processes.
  • Natural sources offer a diverse reservoir of CaM inhibitors for drug discovery.

Purpose of the Study:

  • To provide an updated review of natural products with calmodulin inhibitory properties.
  • To highlight new discoveries of CaM inhibitors from natural sources since 2009.
  • To discuss the structural classes and discovery methods of these natural inhibitors.

Main Methods:

  • Literature review of natural products with reported CaM inhibitory properties.
  • Focus on compounds isolated from fungi and plants.
  • Utilized fluorescence-based methods with biosensors for inhibitor discovery.

Main Results:

  • Identified approximately 70 natural products and synthetic analogues with CaM inhibitory activity.
  • Natural inhibitors belong to structural classes including stilbenoids, polyketides, alkaloids, and peptides.
  • Discovery primarily employed specific, cost-effective, and rapid fluorescence-based biosensor assays.

Conclusions:

  • Natural products, particularly from fungi and plants, remain a valuable source of CaM inhibitors.
  • Continued exploration of natural products is essential for identifying novel drug leads and research tools.
  • Advanced biosensor technology facilitates efficient discovery of specific CaM inhibitors.