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Anti-angiogenic therapies for advanced esophago-gastric cancer

Elisa Fontana1, Francesco Sclafani1, David Cunningham1

  • 1Department of Medicine, The Royal Marsden NHS Foundation Trust, London and Surrey, United Kingdom.

Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology
|December 25, 2014
PubMed

Insights

Anti-angiogenic therapies show antitumor activity in gastric cancer, but survival benefits remain controversial. Further research is needed to clarify their role in treating this disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Neo-vascularization is crucial for tumor growth, involving complex cellular interactions and signaling pathways.
  • Inhibition of angiogenesis is an established treatment for various cancers, but its efficacy in gastric cancer is debated.

Purpose of the Study:

  • To review the role of angiogenesis in gastric cancer.
  • To discuss the safety and effectiveness of anti-angiogenic therapies in clinical trials for gastric cancer.

Main Methods:

  • Literature review using PubMed, ClinicalTrials.gov, and ASCO Annual Meeting Library.
  • Analysis of clinical trial data on anti-angiogenic agents in gastric cancer.

Main Results:

  • Bevacizumab and ramucirumab demonstrate antitumor activity in gastric and esophagogastric junction tumors.
  • Consistent survival advantages over standard treatment have not been observed for all agents, notably bevacizumab.

Conclusions:

  • The therapeutic role of anti-angiogenic agents in gastric cancer requires further investigation.
  • While showing promise, the clinical benefit of these therapies needs to be established through rigorous trials.
Keywords:
Angiogenesisbevacizumabesophageal cancergastric cancerramucirumab

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