Sorafenib-associated facial acneiform eruption
1Division of Dermatology, University of California San Diego, 10991 Twinleaf Court, Twinleaf Court, California, 92131-3643, USA, mitehead@gmail.com.
Dermatology and Therapy
|December 26, 2014
Summary
Sorafenib can cause a rare acne-like facial rash, mimicking chloracne, in cancer patients. Dose reduction or stopping sorafenib (sorafenib) improves these skin side effects.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Sorafenib is an oral multikinase inhibitor used to treat certain cancers.
- Common side effects include hair, nail, and skin issues.
- Acneiform facial lesions are a less common adverse event.
Purpose of the Study:
- To summarize sorafenib-related skin, hair, and nail side effects.
- To review characteristics of patients with sorafenib-induced acneiform facial lesions.
- To present clinical features of these individuals.
Main Methods:
- Literature search of PubMed using terms like 'sorafenib,' 'acneiform eruption,' and 'cutaneous adverse events.'
- Inclusion of case reports and studies on sorafenib's cutaneous and mucosal side effects.
- Evaluation of relevant manuscripts and their citations.
Main Results:
- Five patients developed sorafenib-associated facial acneiform eruption after approximately 4 weeks of treatment (400 mg twice daily).
- Lesions presented as papules/pustules (2 patients) or comedones resembling chloracne (3 patients).
- Topical treatments offered partial improvement; dose reduction or discontinuation led to resolution.
Conclusions:
- Sorafenib-associated facial acneiform eruption is rare, observed in five patients.
- Lesions mimic chloracne in some cases and appear after about 4 weeks of treatment.
- Discontinuation or dose reduction of sorafenib is effective for managing this adverse event.
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