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Related Concept Videos

Acne Infection01:27

Acne Infection

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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[What's new in dermatological therapy?].

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This review covers recent randomized controlled trials for skin conditions like psoriasis, atopic dermatitis, and acne. It highlights new therapies including anti-TNF, ustekinumab, and IL-17 inhibitors for improved patient outcomes.

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AcneAcnéAlopecia areataAtopic dermatitisBiotherapyBiothérapieDermatite atopiquePeladePsoriasisUrticaireUrticaria

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Area of Science:

  • Dermatology and immunology research.
  • Focus on evidence-based therapeutic advancements.

Context:

  • Review of randomized controlled trials (RCTs) published October 2013 - September 2014.
  • Inclusion of research with potential for novel therapeutic strategies.

Purpose:

  • To summarize recent RCT findings in dermatology.
  • To identify emerging treatments for various skin diseases.

Summary:

  • Primarily focuses on psoriasis treatments: anti-TNF, ustekinumab, IL-17 inhibitors, IL-23 inhibitors, anti-CD6, and ponesimod.
  • Includes updates on atopic dermatitis, urticaria, acne, bullous diseases, alopecia areata, skin infections, acne rosacea, and leg ulcers.

Impact:

  • Provides a concise overview of cutting-edge dermatological treatments.
  • Informs clinicians and researchers about the latest therapeutic perspectives in dermatology.