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Updated: Apr 19, 2026

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood
Published on: January 9, 2018
Demyelinating disease and anti-N-methyl-D-aspartate receptor immunoglobulin G antibodies: a case report
Anne Waschbisch1, Bernd Kallmünzer, Stefan Schwab
1Department of Neurology, Friedrich-Alexander University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany. Anne.Waschbisch@uk-erlangen.de.
Background:
Anti-N-methyl-D-aspartate receptor immunoglobulin G antibodies directed against the GluN1 subunit are considered highly specific for anti-N-methyl-D-aspartate receptor encephalitis, a severe clinical syndrome characterized by seizures, psychiatric symptoms, orofacial dyskinesia and autonomic dysfunction.
Case Presentation:
Here we report a 33 year old Caucasian male patient with clinically definite multiple sclerosis who was found to be positive for anti-N-methyl-D-aspartate receptor antibodies. Rituximab therapy was initiated. On the 18 months follow-up visit the patient was found to be clinically stable, without typical signs of anti-N-methyl-D-aspartate receptor encephalitis.
Conclusion:
Our findings add to the growing evidence for a possible association between anti-N-methyl-D-aspartate receptor encephalitis and demyelinating diseases.
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