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Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer
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Microenvironmental regulation of therapeutic response in cancer

Florian Klemm1, Johanna A Joyce1

  • 1Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Trends in Cell Biology
|December 27, 2014
PubMed

Insights

The tumor microenvironment (TME) influences cancer progression and treatment outcomes. Understanding its complex role in resistance and efficacy is key for developing new cancer therapies.

Area of Science:

  • Oncology
  • Cancer Biology
  • Immunology

Background:

  • The tumor microenvironment (TME) is crucial in cancer progression, metastasis, and response to therapy.
  • The TME can mediate resistance to cancer treatments through intrinsic or acquired mechanisms.
  • Conversely, the TME can also enhance the effectiveness of cancer therapies.

Purpose of the Study:

  • To review recent advancements in understanding the TME's role in cancer therapy.
  • To discuss therapeutic strategies targeting the TME for improved cancer treatment.

Main Methods:

  • Literature review of recent studies on the tumor microenvironment and cancer therapy.
  • Analysis of mechanisms of TME-mediated resistance and efficacy enhancement.
  • Identification of potential therapeutic targets within the TME.

Main Results:

  • The TME significantly impacts therapeutic efficacy, leading to both resistance and enhanced treatment response.
  • Mechanisms include co-option of structural elements and signaling networks, and stromal responses to therapy.
  • The TME presents multifaceted opportunities for therapeutic intervention.

Conclusions:

  • Targeting the tumor microenvironment is a promising strategy for overcoming therapeutic resistance.
  • Further research into TME-cancer interactions can lead to novel and more effective cancer treatments.
  • Interventions modulating the TME could significantly improve patient outcomes in oncology.
Keywords:
chemotherapyimmunotherapyradiotherapystromatherapeutic resistancetumor microenvironment

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