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Use of a Poroelastic Model to Predict Intramuscular Pressure.

D A Morrow¹, G M Odegard², K R Kaufman

¹Motion Analysis Laboratory, Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55906.

Poromechanics V : Proceedings of the Fifth Biot Conference on Poromechanics, July 10-12, 2013, Vienna, Austria. Biot Conference on Poromechanics (5Th : 2013 : Vienna, Austria)

|December 27, 2014

Summary

This study developed a computational poroelastic model to predict interstitial muscle fluid pressure (IMP) in skeletal muscle. The model accurately estimated IMP, offering a non-invasive method for assessing muscle tension clinically.

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Area of Science:

Biomechanics
Computational Biology
Muscle Physiology

Background:

Clinical measurement of skeletal muscle tension is challenging.
Interstitial muscle fluid pressure (IMP) is a potential indicator of muscle tension.
A computational model is needed to understand IMP variations.

Purpose of the Study:

To determine material properties of skeletal muscle using inverse finite element analysis.
To develop and validate a poroelastic model for predicting IMP.
To assess the model's accuracy in predicting IMP compared to experimental data.

Main Methods:

Inverse finite element analysis with a poroelastic constitutive formulation.
Load-relaxation tests (longitudinal and transverse uniaxial) on excised skeletal muscle.
Comparison of model-estimated pore pressure with experimental IMP measurements.

Main Results:

Skeletal muscle exhibits transverse isotropy under load-relaxation.
Negative drained Poisson's ratios were observed in longitudinal and transverse loading.
The poroelastic model accurately predicted the development of IMP.

Conclusions:

A poroelastic model can effectively predict interstitial muscle fluid pressure.
This modeling approach offers a promising method for non-invasive muscle tension assessment.
Further research can refine the model for clinical applications.