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Updated: Apr 19, 2026

Orthotopic Hind Limb Transplantation in the Mouse
Published on: February 12, 2016
Transplantation: a brief history
Joseph Yoav Dangoor1, David N Hakim, Rajinder Pal Singh
1From the Royal Free Hospital, London UK.
Abstract:
Developments in transplantation have progressed dramatically over the past century. Current research is underway to optimize immune modulation, genetically engineering animals for xenografting, and breakthroughs are occurring in regenerative medicine. However, pioneering live-donor transplantation has transformed transplantation in the organ shortage, and these contribute an increased proportion of transplanted organs. Live-donor transplantation is associated with better long-term outcomes, and techniques to recover organs have become less invasive. We set out to examine the evolution of transplantation from its historic beginnings to the developments that make it successful today.
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