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Neurodevelopment and phenotype-modulating functions of S100B protein: a pilot study.
D M Davydov1, A V Lobanov2, S G Morozov3
1Sholokhov Moscow State University for the Humanities, The Russian Institute for Advanced Study and Institute of Neurosciences and Cognitive Research, Verkhnyaya Radishevskaya 16-18, Moscow 109240, Russia; Institute of General Pathology and Pathophysiology RAMS, Baltiyskaia ul. 8, Moscow 125315, Russia.
Physiology & Behavior
|December 28, 2014
Summary
Maternal S100B protein is crucial for infant development. A deficit in this protein leads to developmental delays and altered fear responses in neonates, impacting their long-term behavior.
Area of Science:
- Neuroscience
- Developmental Biology
- Maternal-Fetal Medicine
Background:
- The role of maternal neurotrophic proteins in infant development is not fully understood.
- S100B protein is present in maternal blood and milk, suggesting a potential role in neonate development.
Purpose of the Study:
- To investigate the impact of an induced deficit of active S100B protein on neonate development.
- To examine the effects of S100B protein on morphological and neurobehavioral outcomes in offspring.
Main Methods:
- Newborn mice from mothers immunized or sham-immunized against S100B were used.
- Offspring underwent behavioral tests and morphological assessments from birth to weaning.
Main Results:
- Pups of S100B-immunized mothers exhibited morphological issues, including poor weight gain and fur development.
- Delayed neurobehavioral maturation and deficits in neuromotor functions were observed in these pups.
- A significant impact on fear/orienting processes and locomotion was noted.
Conclusions:
- S100B protein is a key factor in neuro- and morphological development, influencing phenotype.
- Suppression of S100B activity results in slower neonatal development and a fearless phenotype.
- This study elucidates a mechanism for neuroplastic regulation of risk-taking behaviors.
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