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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Accessory Structures of the Skin: Sebaceous Glands01:21

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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The Skin Microbiota

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The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
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Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
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Scabies.

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|December 30, 2014
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This summary is machine-generated.

This systematic review evaluated scabies treatments. Topical and oral medications like permethrin and ivermectin were assessed for effectiveness and safety in managing this common public health issue.

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Area of Science:

  • Dermatology
  • Public Health
  • Evidence-Based Medicine

Background:

  • Scabies is a widespread public health concern, endemic in resource-poor regions and prevalent in institutionalized populations in industrialized countries.
  • Understanding effective treatments is crucial for managing scabies outbreaks and individual cases.

Purpose of the Study:

  • To systematically review the clinical effectiveness and safety of topical and systemic treatments for scabies.
  • To answer key clinical questions regarding scabies interventions.

Main Methods:

  • Systematic review of medical literature up to July 2013, including Medline, Embase, and The Cochrane Library.
  • Inclusion of five studies meeting predefined criteria and assessment of evidence quality using the GRADE system.
  • Incorporation of safety alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • The review identified and evaluated five studies on scabies interventions.
  • A GRADE evaluation was performed to assess the quality of evidence for the included treatments.

Conclusions:

  • The systematic review provides information on the effectiveness and safety of several scabies interventions.
  • Key treatments examined include topical benzyl benzoate, crotamiton, malathion, permethrin, sulfur compounds, and oral ivermectin.