Related Experiment Video
Updated: Apr 19, 2026

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
Published on: April 29, 2011
Determinants of pressure drift in Manoscan(™) esophageal high-resolution manometry system
1Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA.
Background:
Manoscan(™) is one of the commonly used high-resolution manometry (HRM) systems with declared measurement accuracy of 1-2 mmHg. However, the accuracy of pressure measurements is limited by development of pressure drift (PD) throughout recording. To date, there has been no systematic investigation to identify the factors contributing to PD. The aim of the present study was to characterize the frequency and magnitude of PD in Manoscan(™) system and identify the factors contributing to PD.
Methods:
Records of 560 consecutive clinical esophageal HRM studies recorded by six distinct HRM catheters were retrospectively reviewed. PD was defined as the residual pressure measurement by each sensor immediately after removal of the catheter. Non-parametric locally weighted regression analysis was performed to assess the effect of duration of study, number of prior uses of a catheter, peak and average pressure exposure during a study on the PD.
Key Results:
The majority (95%) of clinical manometry studies showed a non-negligible PD of more than 5 mmHg. The overall PD was 13 ± 5 mmHg and the sensor with greatest amount of PD showed 23 ± 12 mmHg of drift. The upper esophageal sphincter showed the highest PD. Average pressure exposure of a sensor throughout the recording was the most important predictor of PD. PD inversely correlated with number of prior uses of a catheter.
Conclusions & Inferences:
The PD preferentially affects esophageal high-pressure zones, and strongly correlates with 'average pressure exposure' of a sensor during manometry. Available algorithms of the analysis software do not adequately correct the PD.
More Related Videos
08:25Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship
Published on: January 8, 2019
11:26Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
Published on: December 10, 2014
Related Concept Videos
Definition and Measurement of Pressure: Atmospheric Pressure, Barometer, and Manometer
Pressure Relationships in Thoracic Cavity
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
Measurement of Fluid Pressure
A basic form of manometer is the piezometer, a vertical tube open at the top and filled with the same...
Pressure Variation in a Fluid at Rest
When measuring pressure at two different levels within the fluid, the difference in...