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Low Prevalence of Parvovirus 4 in HIV-infected Children in Denmark

Vibeke Rosenfeldt1, Päivi Norja, Ellinor Lindberg

  • 1From the *Department of Paediatrics, Hvidovre University Hospital, Copenhagen, Denmark; †Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland; ‡Department of Microbiological Diagnostics and Virology, Statens Serum Institut, Copenhagen, Denmark; §Laboratory Services (HUSLAB), Helsinki University Central Hospital, Helsinki, Finland; and ¶College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.

The Pediatric Infectious Disease Journal
|December 30, 2014
PubMed

Insights

Parvovirus 4 (PARV4) infection was detected in 8.7% of HIV-infected children. Seropositivity correlated with lower CD4 counts, suggesting a link between PARV4 and pediatric HIV progression.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Immunology

Background:

  • Parvovirus 4 (PARV4) is a known pathogen associated with Human Immunodeficiency Virus (HIV) infection in adults.
  • The prevalence and impact of PARV4 in HIV-infected children remain understudied.

Purpose of the Study:

  • To investigate the presence of PARV4 infection in a cohort of HIV-infected children.
  • To explore the association between PARV4 seropositivity and clinical parameters in pediatric HIV.

Main Methods:

  • Plasma samples from 46 HIV-infected children (aged 0-16 years) were analyzed for PARV4.
  • Detection methods included assays for PARV4 IgG and IgM antibodies, and PARV4 polymerase chain reaction (PCR).

Main Results:

  • PARV4 IgG was detected in 4 children (8.7%), and PARV4 IgM in 1 child.
  • All PARV4 PCR tests were negative, indicating past or resolved infection rather than active viremia.
  • PARV4 seropositivity was significantly associated with lower CD4+ T-cell counts.

Conclusions:

  • PARV4 infection is present in HIV-infected children.
  • PARV4 seropositivity in this cohort is linked to a compromised immune status (low CD4 count).
  • Further research is needed to understand the clinical significance of PARV4 in pediatric HIV.

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