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Updated: Apr 19, 2026

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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
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Craniofacial growth: evolving paradigms.
Cranio : the Journal of Craniomandibular Practice
|December 31, 2014
Summary
This review synthesizes craniofacial growth theories, integrating scientific advancements to promote a patient-centered orthodontic approach. It shifts focus from predetermined treatments to individualized, multidisciplinary care for better outcomes.
Area of Science:
- Craniofacial biology
- Orthodontics
- Developmental science
Background:
- Craniofacial growth has been explained by various theories including genetic, synthetic, and functional matrix hypotheses.
- Multidisciplinary expertise has been applied to understand craniofacial development for optimal orthodontic patient treatment.
Purpose of the Study:
- To review and synthesize recent concepts in craniofacial growth.
- To align these theories with general scientific progress.
- To propose an integrated, multidisciplinary, and person-based approach to craniofacial development and orthodontic treatment.
Main Methods:
- Comprehensive literature search of MEDLINE, EMBASE, Pubmed, CINAHL, and Google Scholar databases.
- Inclusion of grey literature in the search.
- Screening of relevant papers from inception to February 2014.
Main Results:
- New scientific discoveries and insights have significantly advanced the understanding of craniofacial growth.
- This has led to a paradigm shift in orthodontic care.
- The focus has moved towards a more individualized and patient-centered treatment philosophy.
Conclusions:
- Advancements in understanding craniofacial growth enhance orthodontic care quality.
- The approach has evolved from predetermined, sectorial treatments to individualized, multidisciplinary patient-centered strategies.
- This integrated approach aims to improve the overall quality of orthodontic assistance.
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