[The importance of evaluating histopathologic high risk factors in retinoblastoma and the related issues]

Histopathologic high risk factors are core content in the histopathologic examination of enucleated retinoblastoma. Histopathologic high risk factors indicate that the patient has high risk of tumor spreading and metastasizing and should be given systemic adjuvant chemotherapy. Therefore, histopathologic high risk factors can provide important basis for clinicians to determine treatment plan and serve as the important foundation for clinical trials and studies to validate the proposed criteria. The focus of our discussion includes three aspects as follows. How to evaluate histopathologic high risk factors? Can clinical characteristics be used to predict histopathologic high risk factors? Do histopathologic high risk factors have any hint for intra-arterial chemotherapy? The importance of evaluating histopathologic high risk factors in retinoblastoma is emphasized in this article.