Related Experiment Video
Updated: Apr 19, 2026

Inspiratory Muscle Training as an Adjunct to the Treatment of Weaning Failure in Critically Ill Patients: A Practical Guide
Published on: January 30, 2026
[Effect on inspiratory cycling-off synchronization with different expiratory trigger sensitivity level during
Yuqing Chen1, Xingyi Zhang, Kewen Cheng
1Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
This study compared expiratory trigger sensitivity settings on bilevel ventilators during system leaks. The Auto-Trak system demonstrated better patient-ventilator synchrony, especially in obstructive conditions.
Area of Science:
- Respiratory Mechanics
- Mechanical Ventilation
- Biomedical Engineering
Background:
- Noninvasive ventilation is crucial for respiratory support.
- System leaks can impair ventilator performance and patient synchrony.
- Expiratory trigger sensitivity (ETS) is a key setting affecting cycling-off.
Purpose of the Study:
- To compare inspiratory cycling-off synchronization with different expiratory trigger sensitivity (ETS) settings during noninvasive pressure support ventilation (PSV).
- To evaluate ventilator performance under conditions of system leak.
- To assess the impact of ETS adjustments on patient-ventilator synchrony.
Main Methods:
- Two bilevel ventilators were tested using a lung model simulating obstructive and restrictive ventilatory dysfunction.
- Ventilators were set at 15 cmH2O pressure support and 5 cmH2O PEEP.
- Tests were conducted with system air leaks (24-28 L/min), collecting data on cycling delay, tidal volume, and airflow.
Main Results:
- The Auto-Trak system showed significantly less delay cycling in obstructive conditions compared to the Curative Flexo ST 30.
- Adjusting ETS levels influenced tidal volume, inspiratory time, and peak expiratory flow.
- Premature cycling occurred in restrictive conditions with both ventilators; delay cycling was noted with Flexo ST 30 at insensitive ETS settings.
Conclusions:
- Bilevel ventilator performance and cycling-off differ significantly between obstructive and restrictive conditions, likely due to algorithm software.
- Modifying ETS settings can improve ventilatory parameters and patient-ventilator synchrony during air leaks.
- The Auto-Trak system offers comparable results and improved synchronization during PSV compared to conventional ETS adjustments.
Related Concept Videos
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation I: Indication and Settings
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation...
Factors Affecting Pulmonary Ventilation
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Pulmonary Ventilation: Inhalation
Boyle's law becomes particularly pertinent when examining respiratory...

