Related Experiment Video

Updated: Aug 16, 2026

Efficient Recombinant Parvovirus Production with the Help of Adenovirus-derived Systems
13:47

Efficient Recombinant Parvovirus Production with the Help of Adenovirus-derived Systems

Published on: April 23, 2012

[Parvovirus infections in children with hemolytic anemia]

Y Bertrand, G Leverger, G Schaison

    Annales De Pediatrie
    |October 1, 1989
    PubMed

    Insights

    Parvovirus B19 causes acute erythroblastopenia in children with hemolytic anemias, leading to anemia, neutropenia, and thrombopenia. Diagnosis involves detecting specific antibodies or viral DNA, with ongoing research into its exact inhibitory mechanisms on red blood cell progenitors.

    Area of Science:

    • Virology
    • Hematology
    • Pediatrics

    Context:

    • Parvovirus B19 is a known cause of various human diseases.
    • Acute erythroblastopenia is a significant complication in children with chronic hemolytic anemias.

    Purpose:

    • To summarize the role of parvovirus B19 in acute erythroblastopenia.
    • To review diagnostic methods for parvovirus B19 infection.
    • To discuss the impact of parvovirus B19 on red blood cell progenitors.

    Summary:

    • Parvovirus B19, a single-stranded DNA virus, is identified as the primary agent responsible for acute erythroblastopenia episodes in children with chronic hemolytic anemias.
    • Affected children may experience anemia, neutropenia, and thrombopenia, with hematologic disorders typically resolving within ten days.
    • Diagnosis relies on detecting specific IgM antibodies, viral visualization via electron microscopy, or molecular hybridization techniques for viral genome detection.
    • In vitro studies confirm parvovirus B19's inhibitory effect on red cell progenitors like CFU-E, though the precise mechanism requires further elucidation.

    Impact:

    • Advances understanding of viral-induced hematologic disorders in pediatric populations.
    • Highlights the importance of parvovirus B19 in the differential diagnosis of anemia in children.
    • Suggests potential for discovering novel parvovirus-related diseases.

    More Related Videos

    Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus11:18

    Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

    Published on: May 7, 2012

    Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation08:04

    Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

    Published on: July 9, 2014

    Related Concept Videos

    Overview of Hematopoiesis01:20

    Overview of Hematopoiesis

    Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
    Developmental Phases of Hematopoiesis
    Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
    Disorders of Erythrocytes01:27

    Disorders of Erythrocytes

    Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
    Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
    A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
    On the other...
    Chickenpox01:20

    Chickenpox

    Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
    Poliomyelitis01:17

    Poliomyelitis

    Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
    Cytomegalovirus Disease01:27

    Cytomegalovirus Disease

    Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
    Respiratory Syncytial Virus Disease01:29

    Respiratory Syncytial Virus Disease

    Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...