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Erectile Dysfunction and Essential Hypertension: The Same Aging-related Disorder?
Raul I Clavijo1, Martin M Miner, Jacob Rajfer1
1Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Reviews in Urology
|December 31, 2014
Summary
Erectile dysfunction (ED) and essential hypertension may stem from the same aging-related smooth muscle dysfunction. This panvascular smooth muscle myopathy affects both penile and arterial systems, suggesting a shared underlying cause for these common conditions.
Area of Science:
- Vascular Biology
- Urology
- Cardiology
Background:
- Erectile dysfunction (ED) is often caused by impaired blood storage in the corpora, linked to corporal smooth muscle dysfunction.
- This dysfunction is frequently an aging-related process in men.
Purpose of the Study:
- To hypothesize that aging-related smooth muscle dysfunction in the penis is identical to that in the arterial system.
- To propose this panvascular smooth muscle myopathy as the cause of essential hypertension.
Main Methods:
- Comparative analysis of corporal and arterial smooth muscle.
- Correlation of aging-related dysfunction in both systems.
Main Results:
- Corporal smooth muscle dysfunction is a primary factor in ED.
- Aging-related smooth muscle dysfunction is hypothesized to occur in both penile and arterial systems.
Conclusions:
- ED and essential hypertension may represent the same disorder affecting different organ systems.
- A panvascular smooth muscle myopathy could be the unifying cause for both conditions.
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