Related Experiment Video
Updated: Apr 19, 2026
07:43
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
20.2K
MicroRNAs in Human Pituitary Adenomas
Xu-Hui Li1, Elaine Lu Wang2, Hai-Meng Zhou3
1Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China ; Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing, Zhejiang 314006, China.
International Journal of Endocrinology
|December 31, 2014
Summary
MicroRNAs (miRNAs) are key regulators of gene expression. Dysregulated miRNAs are implicated in pituitary adenoma progression, offering potential as therapeutic targets and biomarkers.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- MicroRNAs (miRNAs) are noncoding RNAs regulating gene expression posttranscriptionally.
- Pituitary adenomas are intracranial neoplasms with significant prevalence.
- Emerging evidence links miRNA dysregulation to pituitary adenoma development and progression.
Purpose of the Study:
- To review the dysregulated microRNAs in pituitary adenomas.
- To elucidate the functions of these microRNAs in tumor progression.
- To highlight their potential as therapeutic targets and biomarkers.
Main Methods:
- Literature review of studies on microRNAs in pituitary adenomas.
- Analysis of deregulated miRNAs and their gene targets.
- Synthesis of information on miRNA involvement in cellular processes relevant to pituitary adenomas.
Main Results:
- Identified specific microRNAs that are dysregulated in pituitary adenomas.
- Linked these deregulated miRNAs to key cellular processes including cell cycle control, apoptosis, and invasion.
- Associated miRNA targets with pituitary adenoma progression and treatment response.
Conclusions:
- MicroRNA dysregulation is a significant factor in pituitary adenoma progression.
- Targeting specific microRNAs may offer novel therapeutic strategies.
- Dysregulated microRNAs show promise as diagnostic and prognostic biomarkers for pituitary adenomas.
Related Concept Videos
02:23Abnormal Proliferation
5.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.5K
01:22MicroRNAs
4.4K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.4K
01:22MicroRNAs
25.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
25.1K