[ESBL and carbapenemases in Enterobacteriaceae]

Area of Science:

• Microbiology
• Infectious Diseases
• Antimicrobial Resistance

Context:

• Carbapenemase-producing enterobacteria (CPE) represent a significant and escalating global health challenge.
• CPE infections are associated with high morbidity and mortality rates.
• The pipeline for new antimicrobial agents effective against CPE is limited.

Purpose:

• To review the current landscape of carbapenemase-producing enterobacteria (CPE) infections.
• To identify and discuss potential improvements in therapeutic approaches for CPE treatment.
• To emphasize the need for enhanced strategies in managing CPE infections.

Summary:

• CPE infections are increasingly prevalent worldwide, posing a severe threat due to limited treatment options.
• Existing therapeutic strategies for CPE infections require optimization.
• Further research and development are crucial to combat the rising challenge of CPE.

Impact:

• This review provides critical insights for clinicians and researchers managing CPE infections.
• It underscores the urgent need for innovative therapeutic strategies to combat antimicrobial resistance.
• The findings aim to guide the development of more effective treatments against CPE, improving patient outcomes.